1905
the Lloyd Street Synagogue once again becomes home to a Jewish congregation, Shomrei Mishmeres. Its spiritual leader, Rabbi Avraham Schwartz, becomes known as the "chief rabbi" of the Orthodox East European Jewish community. Shomrei Mishmeres occupies the Synagogue until disbanding in the 1950s. Shomrei Mishmeres Hakodesh (1905-1963), one of
the leading Orthodox congregations of the East European immigrant community.
1958
With most of its membership base having moved from East Baltimore, the dwindling Shomrei Mishmeres Congregation contemplates selling the deteriorating Lloyd Street Synagogue to commercial buyers. Wilbur Hunter, director of the Peale Museum, learns of the potential sale and alerts the Baltimore Jewish community to the urgent need to save the building from possible destruction. The Baltimore Board of Rabbis appoints a committee to investigate how the historic landmark might be preserved.
1960
The Jewish Historical Society of Maryland is created, with the mission to acquire, renovate, and maintain the Lloyd Street Synagogue. Four years later
the partially-restored Synagogue is dedicated and opened to the public.